Ahmed Musa, Samuel Chukwueze, and Zaidu Sanusi have all pulled out of the Super Eagles friendly against Mexico.
Due to various reasons, three other players, Samson Tijani, Alhassan Yusuf, and Azubuike Okechukwu, will not participate in the game.
Defender Leon Balogun has been ruled out of the friendly against the North Americans, due to a calf injury.
Balogun suffered the injury while playing for Rangers in their Scottish Cup triumph against Hearts last Saturday.
Players were forced to withdraw from the game due to visa issues, injuries, and club commitments.
Early in the week, Emmanuel Dennis, Maduka Okoye, and Umar Sadiq all withdrew out of the game and the match against Ecuador.
Terem Moffi, Adeleye Adeleke, and Innocent Bonke have taken their places.