Erik ten Hag has made three changes to the side that lost at West Ham last weekend.
One of those switches is enforced, with Marcus Rashford dropping out of the squad through injury, while Wout Weghorst and Tyrell Malacia are on the bench.
Raphael Varane is straight back into the starting XI after returning from a month out through injury, meaning Luke Shaw moves to left-back.
Jadon Sancho and Anthony Martial come into the attack, with Bruno Fernandes likely to move into the No 10 position.
Man Utd team news
Team to play Wolves: De Gea; Wan-Bissaka, Lindelof, Varane, Shaw; Casemiro, Eriksen; Antony, Fernandes, Sancho; Martial.
Subs: Butland, Maguire, Malacia, Fred, Dalot, Weghorst, Pellistri, Elanga, Garnacho.
Wolves team news
Team to play Man Utd: Bentley; Semedo, Dawson, Kilman, Toti; Nunes, Neves, Lemina, Neto; Cunha, Costa.
Subs: Sa, Collins, Jimenez, Podence, Hwang, Sarabia, Gomes, A. Traore, Bueno.