Erik ten Hag makes six changes from the Manchester United 11 that began the Carabao Cup final win over Newcastle on Sunday.
In come Tyrell Malacia, Victor Lindelof, Harry Maguire, Scott McTominay, Marcel Sabitzer and Alejandro Garnacho.
Marcus Rashford, who has scored 17 club goals in 19 matches since the World Cup, is on the bench, alongside Casemiro and Raphael Varane, but Jadon Sancho is not in the squad.
Manchester United XI: De Gea, Malacia, Lindelof, Maguire, Dalot, McTominay, Sabitzer, Garnacho, Fernandes, Antony, Weghorst.
Subs: Heaton, Martinez, Varane, Wan-Bissaka, Pellistri, Fred, Casemiro, Rashford, Elanga.
David Moyes makes four changes to the West Ham side, three of them enforced.
Striker Danny Ings, who scored twice in the 4-0 win over Nottingham Forest at the weekend, is cup-tied having played for Aston Villa in the third round before his move to the Hammers in the January transfer window.
Goalkeeper Lukasz Fabianski is out with a fractured cheekbone and eye socket, with Vladimir Coufal also missing because of a heel injury.
In come Alphonse Areola, Emerson Palmieri and Michail Antonio, while Pablo Fornals starts with Jarrod Bowen dropping to the bench.
West Ham XI: Areola, Johnson, Aguerd, Ogbonna, Emerson, Fornals, Rice, Soucek, Benrahma, Paqueta, Antonio.
Subs: Anang, Cresswell, Scamacca, Lanzini, Downes, Bowen, Kehrer, Swyer, Mubama.