Erik ten Hag has made three changes to the Manchester United side who beat Everton on the weekend.
Ronaldo starts up front, while Casemiro retains his place in midfield.
Tyrell Malacia returns at left-back, replacing Luke Shaw, Fred comes in for Christian Eriksen in midfield and the injured Anthony Martial is not in the squad.
Man Utd XI: De Gea, Dalot, Lindelof, Martinez, Malacia, Casemiro, Fred, Antony, Fernandes, Rashford, Ronaldo.
Subs: Heaton, Dubravka, Eriksen, Varane, Shaw, Sancho, Pellistri, Elanga, McTominay, Garnacho, Iqbal.
Omonia Nicosia XI: Uzoho, Matthews, Lang, Miletic, Yuste, Kitsos, Panagiotou, Cassama, Charalampous, Kakoulli, Bruno.
Subs: Panayi, Psaltis, Loizou, Barker, Papoulis, Lecjaks, Ansarifard, Zachariou, Diskerud, Venizelou, Savva, Bezus.