Manchester United manager Erik ten Hag has made six changes from the side that beat Reading 3-1 in the FA Cup on Saturday.
Fred replaces the injured Eriksen in midfield. Heaton, Varane, Martinez, Shaw and Garnacho also come into the starting line-up.
Martial and Sancho are named among the substitutes. Rashford drops to the bench along with De Gea, Lindelof, Maguire and Malacia.
Nottingham Forest boss Steve Cooper has opted to make four changes following last Wednesday’s 3-0 loss to United in the Carabao Cup semi-final first leg.
Neco Williams, Boly, Mangala and Lingard all start. Aurier, Worrall, Danilo and Gibbs-White drop out.
Nottingham Forest starting XI: Hennessey, N Williams, McKenna, Boly, Lodi, Freuler, Scarpa, Mangala, Lingard, Johnson, Surridge.
Man Utd starting XI: Heaton, Wan-Bissaka, Varane, Martinez, Shaw, Casemiro, Fred, Antony, Fernandes, Garnacho, Weghorst.
Subs: De Gea, Lindelof, Maguire, Martial, Rashford, Malacia, Sancho, Pellistri, Mainoo.