Erik ten Hag makes three changes to the Manchester United side that started the defeat at Tottenham last weekend.
Luke Shaw and Mason Mount are out injured, Alejandro Garnacho drops to the bench and Diogo Dalot, Christian Eriksen and Anthony Martial come into the starting XI.
Manchester United XI: Onana, Wan-Bissaka, Varane, Martinez, Dalot, Casemiro, Eriksen, Antony, Fernandes, Rashford, Martial.
Subs: Henderson, Lindelof, Maguire, Sancho, Pellistri, McTominay, Fernandez, Gore, Garnacho.
There are two changes to the Nottingham Forest side that beat Sheffield United last time out.
Ryan Yates and fit-again Ola Aina start in place of Orel Mangala, who is not in the squad, and Neco Williams.
New signing Gonzalo Montiel is named among the substitutes.
Nottingham Forest XI: Turner, Boly, Worrall, McKenna, Aurier, Danilo, Yates, Aina, Johnson, Gibbs-White, Awoniyi.
Subs: Horvath, N Williams, Kouyate, Wood, Niakhate, Elanga, Freuler, Montiel, Hwang.