Cristiano Ronaldo returns to the United starting lineup, one of four changes with Fred, Raphael Varane, and Jadon Sancho coming in, with Victor Lindelof, Christian Eriksen, Marcus Rashford and Anthony Martial dropping out.
Man Utd XI: De Gea, Dalot, Varane, Martinez, Shaw, Casemiro, Fred, Bruno Fernandes, Antony, Sancho, C Ronaldo.
Substitutes: Heaton, Lindelof, Rashford, Tyrell Malacia, Pellistri, Elanga, Garnacho, Iqbal, Mainoo.
Just the one change for Newcastle, with Joelinton returning in place of Joe Willock.
Newcastle XI: Pope, Trippier, Schar, Botman, Burn, Longstaff, Brunoi Guimarães, Joelinton, Almiron, Wilson, Murphy.
Substitutes: Karius, Lascelles, Shelvey, Lewis, Targett, Wood, Fraser, Willock, Anderson.