Manchester United manager Erik ten Hag has made three changes from the team which held on to beat Crystal Palace 2-1 on Saturday.
Deadline Day loan-signing Marcel Sabitzer replaces the suspended Casemiro, who was sent off on the weekend, to make his first start for United.
Alongside him in midfield is Fred, who keeps his place in the team in the absence of the injured Christian Eriksen.
Right-back Diogo Dalot makes his first start since January 10 after recovering from injury, taking the place of Aaron Wan-Bissaka.
Alejandro Garnacho starts in place of Antony after he picked up a knock against Palace on Saturday and is joined by Marcus Rashford and Wout Weghorst in the front three.
Jadon Sancho again has to settle for place on the bench as Ten Hag gradually integrates him back into the swing of first-team football, while Anthony Martial is missing from the matchday squad again as his injury struggles continue.
Man Utd team news – Sabitzer full debut, Dalot returns
Team to face Leeds: De Gea, Dalot, Varane, Martinez, Shaw; Fred, Sabitzer, Fernandes; Rashford, Weghorst, Garnacho.
Subs: Heaton, Malacia, Lindelof, Maguire, Pellistri, Iqbal, Mainoo, Sancho, Elanga.
Leeds team news – McKennie makes first start | Cooper not in squad
Team to face Man Utd: Meslier; Ayling, Koch, Wober, Struijk; Adams, McKennie; Sinisterra, Harrison, Gnonto; Bamford.
Subs: Robles, Firpo, Kristensen, Gyabi, Aaronson, Summerville, Greenwood, Rutter, Joseph.