Raphael Varane is unexpectedly missing from Manchester United squad, owing to a minor injury according to reports.
That means Harry Maguire is given a chance to make his mark alongside Lisandro Martinez.
With no Casemiro, Erik ten Hag has decided to go with the axis of Scott McTominay and Marcel Sabitzer whilst Fred is only on the bench.
Joao Palhinha’s return from suspension will give the visitors a boost. They’ve been well off their best level in their past two Premier League games without the destructive midfielder at the heart of their system.
Marco Silva may also reflect on his side’s 2-1 defeat to United at Craven Cottage, where only a last-gasp Alejandro Garnacho goal denied them a deserved point in November. Garnacho is out injured this time, while Casemiro starts a four-game suspension.
Fulham team news
Team to play Man Utd: Leno, Tete, Diop, Ream, Robinson, Palhinha, Reed, Andreas, De Cordova-Reid, Mitrovic, Willian
Subs: Rodak, Tosin, Cedric, Lukic, Cairney, Wilson, Solomon, James, Vinicius
Man Utd team news
Team to play Fulham: De Gea, Wan-Bissaka, Martinez, Maguire, Shaw, McTominay, Sabitzer, Fernandes, Sancho, Rashford, Weghorst
Subs: Butland, Dalot, Lindelof, Malacia, Fred, Mainoo, Antony, Pellistri, Elanga