There are two Manchester United changes to the side who beat Luton last weekend and both are enforced.
Left-back Luke Shaw has sustained a muscle injury and will be out for a few months with Victor Lindelof replacing him.
Striker Rasmus Hojlund is also out injured, so 19-year-old youngster Omari Forson comes in for his first United start.
Man Utd XI: Onana, Lindelof, Maguire, Varane, Dalot, Casemiro, Mainoo, Rashford, Fernandes, Garnacho, Rashford, Forson.
Subs: Bayindir, Amrabat, Eriksen, Diallo, Antony, Evans, McTominay, Kambwala, Collyer.
Fulham boss Marco Silva makes six changes to the side who lost against Aston Villa last time out.
Calvin Bassey and Tosin Adarabioyo replace Issa Diop and Tim Ream in defence.
Harrison Reed, Harry Wilson, Alex Iwobi, Sasa Lukic are the four changes in midfield.
Tom Cairney and De Cordova-Reid drop to the bench.
Hugely influential midfielder Joao Palhinha begins a two-match ban as a result of accumulating 10 bookings and Willian is not in the squad at all.
Armando Broja has recovered from illness and is on the bench.
Fulham XI: Leno, Castagne, Bassey, Tosin, Robinson, Reed, Wilson, Iwobi, Pereira, Lukic, Muniz.
Subs: Rodak, Tete, Broja, Cairney, Adama, Ballo-Touré, Ream, De Cordova-Reid, Diop.