Erik ten Hag has rotated perhaps more than expected, making seven changes from the win over Burnley.
There are returns for Harry Maguire and Mason Mount whilst Sofyan Amrabat makes his full debut, potentially at right-back in a lopsided United starting XI that only contains one natural full-back. Anthony Martial leads the line.
Bruno Fernandes, Rasmus Hojlund and Marcus Rashford are all on the bench.
Crystal Palace team news
Team to play Man Utd: Henderson, Clyne, Holding, Richards, Mitchell, Doucoure, Riedewald, Schlupp, Rak-Sakyi, Ayew, Mateta.
Subs: Johnstone, Ward, Guehi, Andersen, Hughes, Ozoh, Eze, Ebiowei, Ola-Adebomi.
Man Utd team news
Team to play Crystal Palace: Onana, Amrabat, Maguire, Varane, Dalot, Casemiro, Hannibal, Mount, Pellistri, Garnacho, Martial.
Subs: Bayindir, Heaton, Evans, Lindelof, Fernandes, Gore, Van de Beek, Hojlund, Rashford.