Jordan Henderson returns to the Liverpool starting XI after recovering from injury.
The midfielder missed the last few games before the international break with a hamstring injury.
Henderson’s return is one of three changes from the win against Ajax in the Champions League last time out as Fabio Carvalho and Roberto Firmino also start. Darwin Nunez, Luis Diaz and Diogo Jota are on the bench.
Liverpool XI: Alisson, Alexander-Arnold, Matip, van Dijk, Tsimikas, Henderson, Fabinho, Thiago, Salah, Firmino, Carvalho.
Subs: Gomez, Milner, Adrian, Elliott, Jota, Diaz, Nunez, Arthur, Phillips.
New Brighton boss Roberto de Zerbi makes just one change from Graham Potter’s final starting XI from the 5-2 win against Leicester at the start of September.
Pervis Estupinan is the only player to come into the side. Former Liverpool midfielder Adam Lallana is on the bench.
Brighton XI: Sanchez, Veltman, Dunk, Webster, March, Caicedo, Mac Allister, Estupinan, Gross, Trossard, Welbeck.
Subs: Lamptey, Colwill, Lallana, Sarmiento, Enciso, Undav, Mitoma, Steele, Gilmour.