Aston Villa have made two changes from their 2-0 win at Arsenal.
Matty Cash and Douglas Luiz come in for Diego Carlos and Morgan Rogers, who both start on the bench.
There are also three changes from the first leg last week. Again, Carlos and Rogers drop to the bench with Leon Bailey also among the subs.
Cash, Nicolo Zaniolo and Moussa Diaby come into the XI from that first leg.
Aston Villa team news
Team to play Lille: Martinez, Konsa, Cash, Torres, Digne, Tielemans, Luiz, Diaby, McGinn, Zaniolo, Watkins.
Subs: Diego Carlos, Lenglet, Gauci, Duran, Olsen, Rogers, Kesler-Hayden, Bailey, Iroegbunam, Munroe, Kellyman.
Ligue 1 side Lille have made one change from the first leg.
Yusuf Yazici comes into the XI for Edon Zhegrova, who misses out this evening.
Lille team news
Team to play Aston Villa: Chevalier, Santos, Diakite, Yoro, Ismaily, Andre, Bentaleb, Yazici, Haraldsson, Gudmundsson, David.
Subs: Mannone, Alexsandro Victor, Gomes, Cabella, Ounas, Cavaleiro, Morais, Bouaddi, Toure, Ferrah, Negrel.