Some Inter Miami fans have been caught on camera heading for the exits at DRV PNK Stadium after Lionel Messi being replaced.
The game had not even reached half-time by that point.
Inter Miami went on to win 4-0 and kept themselves in the hunt for a play-off berth.
But it remains to be seen when Messi will be called upon again as Martino has already ruled him out of a derby date with Orlando City on Sunday.
A U.S. Open Cup final clash with the Houston Dynamo is set to take place next Wednesday, with Messi and Co setting their sights on more major silverware.
The seven-time Ballon d’Or winner was returned to Tata Martino’s starting XI for a meeting with Toronto FC on Wednesday.
He lasted just 37 minutes of that contest before being forced off with a recurrence of the injury that he picked up while on World Cup qualifying duty with Argentina.