The FA Cup replays will be scrapped from next season, with the first round proper with fixtures now set to be played exclusively on weekends.
The FA and the Premier League have a new agreement for a minimum of six years to “strengthen” the competition with “new and exclusive calendar windows”.
As part of the changes, the competition will be played without replays from the first round proper which has been agreed “in light of changes to the calendar driven by the expanded UEFA competitions”.
The FA had already ditched replays from the fifth round onwards.
The fourth and fifth rounds plus the quarter-finals will be played without Premier League fixtures taking place on the same weekends.
The fourth round will have an extended fixture window from Friday to Wednesday.
The final will now take place on the penultimate weekend of the Premier League season, with no top-flight fixtures taking place on the same day or night before.