Frank Lampard makes one change to the Everton side that won 2-1 at Southampton last weekend.
It comes in the forward line with Anthony Gordon replacing Dwight McNeil, who drops down to the bench.
Everton: Pickford, Coleman, Coady, Tarkowski, Mykolenko, Onana, Gueye, Iwobi, Gordon, Maupay, Gray.
Subs: Begovic, Keane, McNeil, Calvert-Lewin, Davies, Vinagre, Rondon, Garner, John.
Erik ten Hag makes four changes to the Manchester United team that lost 6-3 to Manchester City in the derby last Sunday.
Summer signing Casemiro makes his first Premier League start in midfield, while Victor Lindelof, Luke Shaw and Anthony Martial also come in.
Raphael Varane, Tyrell Malacia, Scott McTominay and Jadon Sancho all drop down to the bench.
Cristiano Ronaldo, who started in the Europa League, is on the bench too.
Man Utd: De Gea, Dalot, Lindelof, Martinez, Shaw, Casemiro, Eriksen, Antony, Fernandes, Rashford, Martial.
Subs: Heaton, Ronaldo, Malacia, Fred, Varane, Sancho, Pellistri, Elanga, McTominay.