Two changes to the Arsenal team that beat Manchester United before the international break and they are both significant.
In goal, summer signing David Raya is preferred to Aaron Ramsdale, with the Spaniard selected to make his debut following his move from Brentford in August.
In midfield, meanwhile, Fabio Vieira is favoured over the out-of-form Kai Havertz, who drops to the bench for the first time since his £65m move from Chelsea.
Eddie Nketiah once again leads the line, with Gabriel Jesus only on the bench.
Dwight McNeil makes his first start of the season after recovering from an ankle injury as one of two changes from the 2-2 draw with Sheff Utd.
Vitalii Mykolenko finally gets his first Premier League minutes of the season after sitting on the bench for all four of Everton’s games so far, replacing Nathan Patterson in defence.
James Garner is the other player to drop to the bench, where he is joined by the returning Dominic Calvert-Lewin – as well as Youssef Chermiti. After so long scrabbling around for a senior striker, Everton have three in their squad.
Arsenal team news
Team to play Everton: Raya, White, Saliba, Gabriel, Zinchenko, Rice, Odegaard, Vieira, Saka, Martinelli, Nketiah.
Subs: Jesus, Smith Rowe, Kiwior, Tomiyasu, Trossard, Jorginho, Nelson, Havertz.
Everton team news
Team to play Arsenal: Pickford, Young, Tarkowski, Branthwaite, Mykolenko, Onana, Doucoure, Gueye, Danjuma, Beto, McNeil.
Subs: Virginia, Patterson, Keane, Godfrey, Garner, Dobbin, Onyango, Chermiti, Calvert-Lewin.