Kepa Arrizabalaga is the notable absentee from the Chelsea squad as he reportedly edges closer to joining Real Madrid on loan.
Robert Sanchez, the £25m arrival from Brighton, starts as goalkeeper with a back five ahead of him that includes summer signing Axel Disasi making his debut for Chelsea.
Levi Colwill, also making his first competitive Chelsea appearance, plays alongside him with Thiago Silva.
In midfield is Enzo Fernandez, Conor Gallagher and Carney Chukwuemeka.
Up top is Raheem Sterling with Chelsea new-boy Nicolas Jackson, another debutant.
Liverpool hand debuts to Alexis Mac Allister and Dominik Szoboszlai in an attacking line-up from Jurgen Klopp.
The back five is as expected with Trent Alexander-Arnold and Andy Robertson either side of Ibrahima Konate and Virgil van Dijk with Alisson in goal.
The two midfielders are joined by Cody Gakpo it seems without an obvious holding midfielder. Curtis Jones, who is on the bench, had been performing that role in pre-season.
The attack is made up of Mohamed Salah, Diogo Jota and Luis Diaz.
Darwin Nunez and Harvey Elliott are Liverpool’s only senior attacking options off the bench, which includes youngsters Ben Doak and James McConnell.
Chelsea team news
Team to play Liverpool: Sanchez, Disasi, Colwill, Silva, James, Chilwell, Fernandez, Gallagher, Sterling, Chukwuemeka, Jackson
Subs: Bergstrom, Cucurella, Mudryk, Madueke, Ugochukwu, Santos, Gusto, Maatsen, Burstow
Liverpool team news
Team to play Chelsea: Alisson, Robertson, Van Dijk, Konate, Alexander-Arnold, Mac Allister, Szoboszlai, Gakpo, Jota, Salah, Diaz
Subs: Kelleher, Gomez, Nunez, Jones, Elliott, Tsimikas, Matip, Doak, McConnell