This year, Italy has the most representatives in the last eight with three clubs in Friday’s draw (AC Milan, Inter Milan and Napoli).
Two from the Premier League (Manchester City, and Chelsea) just one representative from the other major leagues: Real Madrid (Spain), Benfica (Portugal) and Bayern Munich (Germany).
From the group stage up until the Round of 16, teams from the same country could not face each other – but they can now, from the quarter finals onwards.
This year, it means we could be treated to a Derby della Madonnina – a Milan derby or an all-Italian, north versus south quarter final (if either of the Milan teams are drawn against Napoli).
There is also a possibility that the two remaining Premier League clubs, Manchester City and Chelsea could meet in the next round.