Liverpool boss, Jurgen Klopp, makes four changes to the side that began their 4-1 defeat against Napoli in their opening Group A.
Left-back Andy Robertson is out with a knee injury, while Joe Gomez, James Milner and Roberto Firmino drop to the bench.
In come Kostas Tsimikas, Joel Matip, Thiago and Diogo Jota with Darwin Nunez also starting as a substitute.
Liverpool XI: Alisson, Alexander-Arnold, Matip, Van Dijk, Tsimikas, Thiago, Fabinho, Elliott, Salah, Jota, Diaz.
Subs: Adrian, Davies, Gomez, Milner, Firmino, Nunez, Carvalho, Arthur, Bajcetic, Phillips
Ajax make one change to the side that started their 5-0 win over Heerenveen in the Eredivisie last Saturday with Davy Klaassen dropping to the bench as Steven Berghuis starts.
Ajax XI: Pasveer, Timber, Bassey, Alvarez, Bergwijn,Taylor, Tadic, Rensch, Blind, Kudus, Berghuis
Subs: Stekelenburg, Gorter, Klaassen, Brobbey, Ocampos, Kaplan, Lucca, Sanchez, Grillitsch, Baas, Regeer, Magallan.