Liverpool’s 68-game unbeaten home run was ended by Burnley on Thursday.
The almost four-year unbeaten league run at Anfield was shattered, as the champions were shocked 1-0.
The Reds took a step backwards in the title race as, 24 hours after Manchester City and Manchester United had taken turns winning to top the Premier League.
Ashley Barnes scored the only goal of the game with seven minutes to play, converting a penalty he won himself after colliding with goalkeeper Alisson.
It was Liverpool’s first home Premier League defeat since April 23, 2017, when they lost 2-1 to Crystal Palace.
Only Chelsea’s run of 86 league games of not losing at Stamford Bridge, which ran to October 2008, was longer.
The result leaves Liverpool six points behind leaders United at the top of the table at the halfway stage of the season. City are four points ahead in second, but also have a game in hand.