Two changes for Brighton. Billy Gilmour makes his first Premier League start for Brighton as Moses Caicedo is suspended after picking up his fifth yellow card at Southampton whilst World Cup hero Alexis Mac Allister should be ready to return next week.
Tariq Lamptey also makes his first league start of the campaign, replacing Joel Veltman who drops to the bench.
Just the one change for Mikel Arteta as Oleksandr Zinchenko replaces Kieran Tierney at left back.
Gabriel Jesus is out until February at the earliest with a knee problem. Emile Smith Rowe remains absent despite recovering from a groin problem that has kept him out since September.
Brighton team news
Team to play Arsenal: Sanchez, Dunk, Colwill, Estupinan, Gilmour, Gross, Lamptey, Lallana, Mitoma, Trossard, March
Subs: Steele, Sarmiento, Enciso, Ferguson, Van Hecke, Moran, Hinshelwood, Veltman, Turns
Arsenal team news
Team to play Brighton: Ramsdale, White, Saliba, Gabriel, Zinchenko, Partey, Xhaka, Odegaard, Saka, Martinelli, Nketiah
Subs: Turner, Holding, Cedric, Vieira, Lokonga, Elneny, Marquinhos, Tierney, Tomiyasu