Erik ten Hag has stuck with the team that started in the epic win over Liverpool in the FA Cup before the international break.
Kobbie Mainoo was struggling with illness earlier this week, but has recovered and starts.
On the bench for United are Lisandro Martinez and Casemiro.
Brentford team news
Team to play Man Utd: Flekken, Zanka, Ajer, Collins, Roerslev, Yarmoliuk, Jensen, Janelt, Lewis-Potter, Wissa, Toney.
Subs: Strakosha, Maupay, Ghoddos, Onyeka, Mbeumo, Damsgaard, Baptiste, Trevitt, Kim
Man Utd team news
Team to play Brentford: Onana, Wan-Bissaka, Varane, Lindelof, Dalot, Mainoo, McTominay, Fernandes, Rashford, Hojlund, Garnacho.
Subs: Heaton, Amrabat, Maguire, Martinez, Mount, Eriksen, Casemiro, Antony, Kambwala.