Barcelona make two changes from the side that won 1-0 away at Villarreal in La Liga on Sunday.
Andreas Christensen and Alejandro Balde are replaced by Marcos Alonso and Jordi Alba in defence.
Manchester United make three changes following their 2-0 victory at rivals Leeds in the Premier League.
Diogo Dalot, Harry Maguire and Marcel Sabitzer make way for Aaron Wan-Bissaka, Raphael Varane and Casemiro.
Man Utd team news
Man Utd starting XI: De Gea, Wan-Bissaka, Varane, Shaw, Malacia, Casemiro, Fred, Sancho, Fernandes, Rashford, Weghorst.
Subs: Heaton, Butland, Lindelof, Maguire, Dalot, Pellistri, Elanga, Garnacho, Iqbal, Mainoo.
Barcelona team news
Barcelona starting XI: Ter Stegen, Kounde, Araujo, Alonso, Alba, Pedri, De Jong, Kessie, Raphinha, Lewandowski, Gavi.
Subs: Pena, Tenas, Fati, Torres, Christensen, Roberto, Garcia, Balde, Casado, Torre, Alarcon.