Mikel Arteta has made three changes from the Arsenal side which drew with Fulham last week.
Gabriel Magalhaes is selected to start for the first time this season following Thomas Partey’s training ground injury.
Oleksandr Zinchenko is back in the XI, too, so after some early-season experimentation, Arsenal will finally deploy the back four which served them so well last term.
Up top, Eddie Nketiah – who scored twice against Man Utd in this fixture last season – comes in for Leandro Trossard. Gabriel Jesus is again on the bench, alongside Takehiro Tomiyasu, who is back from suspension.
Arsenal team news
Team to face Man Utd: Ramsdale, White, Saliba, Gabriel, Zinchenko, Rice, Odegaard, Havertz, Saka, Nketiah, Martinelli.
Subs: Raya, Jesus, Smith Rowe, Kiwior, Tomiyasu, Trossard, Jorginho, Vieira, Nelson.
Man Utd team news
Team to face Arsenal: Onana, Wan-Bissaka, Lindelof, Martinez, Dalot, Casemiro, Eriksen, Fernandes, Antony, Martial, Rashford.
Subs: Bayindir, Maguire, Hojlund, Reguilon, Garnacho, Pellistri, Evans, Gore, Mejbri.