Arsenal make two changes to the side who beat Crystal Palace 1-0 on Monday.
Takehiro Tomiyasu is banned after being shown two yellow cards in that match and Jakub Kiwior comes in for him.
Leandro Trossard starts in place of Eddie Nketiah who drops to the bench.
Gabriel Jesus returns to the bench and could make his first appearance of the season after recovering from a knee injury.
Bukayo Saka sets a new club record by playing in his 83rd consecutive Premier League match, bypassing previous record holder Paul Merson.
Arsenal XI: Ramsdale, Kiwior, White, Saliba, Partey, Odegaard, Rice, Havertz, Saka, Trossard, Martinelli.
Subs: Raya, Gabriel, Jesus, Smith Rowe, Nketiah, Jorginho, Vieira, Nelson, Zinchenko.
Fulham also make two changes to the side who lost 3-0 against Brentford last Saturday.
Captain Tim Ream is suspended after his dismissal during the defeat and Calvin Bassey replaces him, making his first start for the club since signing from Ajax in the summer.
Joao Palhinha starts in place of Harrison Reed after his comeback from injury as a substitute last week.
Fulham XI: Leno, Tete, Diop, Bassey, Robinson, Palhinha, Lukic, Pereira, Wilson, Jimenez, De Cordova-Reid.
Subs: Rodak, Tosin, Reed, Cairney, Adama, Muniz, Mbabu, Vinícius, Harris.