Crystal Palace’s interim manager Paddy McCarthy makes two changes from the side that were beaten 1-0 by Brighton in Patrick Vieira’s final game.
Nathaniel Clyne drops to the bench with the evergreen Joel Ward coming in at right-back.
Albert Sambi Lokonga is ineligible to face his parent club meaning Luka Milivojevic captains the side.
Nineteen-year-old goalkeeper Joe Whitworth retains his place in goal and makes only his second Premier League start in the continued absence of Vicente Guaita.
Rob Holding makes his first Premier League start since the final day of last season as William Saliba misses out due to a back complaint.
That means Ben White continues at right-back, with Takehiro Tomiyasu and Eddie Nketiah not in the matchday squad.
Since his debut, no player has been involved in more goals for Arsenal than the six of Leandro Trossard, who is set to continue in the false nine position with Gabriel Jesus fit enough only for the substitutes’ bench.
Arsenal team news: Saliba absent
Arsenal: Ramsdale; White, Holding, Gabriel, Zinchenko; Partey, Xhaka; Saka, Odegaard, Martinelli; Trossard.
Subs: Turner, Tierney, Jesus, Smith Rowe, Kiwior, Jorginho, Vieira, Nelson, Walters.
Crystal Palace team news: Whitworth in goal again
Crystal Palace: Whitworth; Ward, Andersen, Guehi, Mitchell; Milivojevic, Doucoure, Schlupp; Olise, Edouard, Zaha.
Subs: Goodman, Tomkins, Ayew, Eze, Mateta, Clyne, Hughes, Richards, Ahamada.