Arsenal boss Mikel Arteta makes three changes from the side which drew 2-2 with Bayern Munich in the first leg of their Champions League quarter-final last Tuesday.
Oleksandr Zinchenko, Leandro Trossard and Gabriel Jesus are all recalled to the starting line-up.
Jakub Kiwior, Jorginho and Gabriel Martinelli are the players to miss out and are all named among the substitutes.
Arsenal XI: Raya, White, Saliba, Gabriel, Zinchenko, Odegaard, Trossard, Rice, Saka, Havertz, Jesus
Subs: Ramsdale, Partey, Smith Rowe, Martinelli, Nketiah, Kiwior, Tomiyasu, Jorginho, Vieira
Unai Emery makes two changes to the Aston Villa team which beat Lille 2-1 in their Europa Conference League quarter-final first leg during the week.
Nicolo Zaniolo is named in midfield for Douglas Luiz, who serves the first of a two-match ban after he picked up his 10th yellow card of the season against Brentford last weekend.
Moussa Diaby is preferred to Leon Bailey, who drops to the bench.
Villa XI: Martinez, Konsa, Carlos, Torres, Digne, Zaniolo, Tielemans, Diaby, Rogers, McGinn, Watkins
Subs: Olsen, Cash, Moreno, Chambers, Lenglet, Duran, Kesler-Hayden, Bailey, Iroegbunam