Manchester United make just one change from the goalless draw against Newcastle on Sunday.
Marcus Rashford is fully fit after illness and comes in up front in place of Cristiano Ronaldo.
Former Spurs midfielder Christian Eriksen, who has been ill himself, is on the bench.
Man Utd XI: De Gea, Dalot, Varane, Martinez, Shaw, Casemiro, Fred, Antony, Fernandes, Sancho, Rashford.
Tottenham also make just one change from the side that beat Everton last time out.
Yves Bissouma comes in for the injured Richarlison, who is sweating on his fitness for the World Cup.
Spurs XI: Lloris, Doherty, Romero, Dier, Davies, Perisic, Hojbjerg, Bentancur, Bissouma, Son, Kane.