Barcelona and Real Madrid will staging an El Classico encounter as they are drawn tonfsce each other in the Copa Del Rey semi-final.
Real Betis and Valencia will be facing off in the other last-four tie.
The means the two biggest clubs on Spain will play each other three times in the space of four weeks.
Real Madrid will play host to Barcelona at the Santiago Bernabeu in a La Liga game on March 2.
Barcelona will host Madrid in the first leg which will hold on February 6 while the second led in Madrid will take place February 27.
The final will be played at Benito Villamarin stadium which is the home of Real Betis in Seville on May 25.