The Super Eagles duo of Kelechi Iheanacho and Wilfred Ndidi will not be playing in the Champions League next season.
It is the second year in a row that Leicester City will be missing out the top four places in the Premier League on the last day.
The Foxes lost 4-2 at home to Tottenham Hotspur.
Iheanacho and Ndidi both played for the full 90 minutes, but could do little to prevent Leicester from a damaging defeat.
Brendan Rodgers men had been in the top four all season, but some disappointing results at the business end of the season allowed their rivals to close the gap on them.
They went into Sunday’s clash outside the top four but knew they could still fight their way back should results go their way.